Injectable in situ cross-linking hydrogels for local antifungal therapy
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چکیده
منابع مشابه
Injectable in situ cross-linking hydrogels for local antifungal therapy.
Invasive fungal infections can be devastating, particularly in immunocompromised patients, and difficult to treat with systemic drugs. Furthermore, systemic administration of those medications can have severe side effects. We have developed an injectable local antifungal treatment for direct administration into existing or potential sites of fungal infection. Amphotericin B (AmB), a hydrophobic...
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In Situ Cross-Linking of Polyanionic Polymers to Sustain the Drug Release from Theophylline Tablets
The aim of this study was to develop an extended-release tablet formulation using a new in situ cross-linking method. The effects of polyvalent cations on theophylline release from tablets made with the polyanionic polymers sodium alginate and sodium carboxymethylcellulose, were investigated. Different miliequivalents of the di and tri-valent cation, Ca2+ and Al3+, were added to tablet form...
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The aim of this study was to develop an extended-release tablet formulation using a new in situ cross-linking method. The effects of polyvalent cations on theophylline release from tablets made with the polyanionic polymers sodium alginate and sodium carboxymethylcellulose, were investigated. Different miliequivalents of the di and tri-valent cation, Ca2+ and Al3+, were added to tablet form...
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ژورنال
عنوان ژورنال: Biomaterials
سال: 2010
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2009.11.016